Chemistry and pharmacology of Bidens pilosa: an overview

Bidens pilosa L. (Asteraceae): Botanical Properties, Traditional Uses, Phytochemistry, and Pharmacology

There are 230 to 240 known Bidens species. Among them, Bidens pilosa is a representative perennial herb, globally distributed across temperate and tropical regions. B. pilosa has been traditionally used in foods and medicines without obvious adverse effects. Despite significant progress in phytochemical and biological analyses of B. pilosa over the past few years, comprehensive and critical rev...

Anti-adult T-cell leukemia effects of Bidens pilosa.

We evaluated the effects of Bidens pilosa, a plant found in tropical and subtropical regions, and investigated the molecular pathways responsible for the anti-adult T-cell leukemia (ATL) effect. Water extracts of B. pilosa had growth suppressive effects on human T-cell leukemia virus type 1 (HTLV-1)-infected T-cell lines and ATL cells. B. pilosa extracts arrested cells in G1 cell cycle and indu...

Flavonoids, centaurein and centaureidin, from Bidens pilosa, stimulate IFN- expression

Bidens pilosa is used as an ethnical medicine for bacterial infection or immune modulation in Asia, America and Africa. Here, we employed n IFNpromoter-driven luciferase reporter construct and T cells to characterize immunomodulatory compounds from this plant based on a ioactivity-guided isolation principle. We found that PHA, a positive control, caused a six-fold increase in IFNpromoter activi...

Compilation of secondary metabolites from Bidens pilosa L.

Bidens pilosa L. is a cosmopolitan annual herb, known for its traditional use in treating various diseases and thus much studied for the biological activity of its extracts, fractions and isolated compounds. Polyacetylenes and flavonoids, typical metabolite classes in the Bidens genus, predominate in the phytochemistry of B. pilosa. These classes of compounds have great taxonomic significance. ...

Environmental Pharmacology – An Overview